Lab mixers system.The mixtures were then extruded using a thermo electron process 11 extruder thermo fisher scientic, waltham, ma, usa at a temperature range of 120 c to 190 c, extrusion speed of 201 rpm, 6.1 nm torque and 35 bar pressure.The extruded lament was pelletized using a thermo scientic varicut pelletizer 11m thermo.
Thermo fisher prism varicut pelletizer.Processing parameters were varied in terms of screw speed , feed rate and barrel.Q n temperature t b.A first set of trials was performed with constant barrel temperature t b 180c and feed rate q 3 kgh , for several screw speeds of 100, 300, 500, 700 and 900 rpm.
69 varicut pelletizer thermo fisher scientific, uk and mixed with paracetamol 2g, 5 drug 70 ww for 10 minutes in a turbula t2f shakermixer glen mills inc., usa.The mixture was 71 extruded using a singlescrew filabot hot melt extruder filabot, usa at 180 c through a 72 1.75 mm diameter nozzle screw speed 35 rpm.
Pdf | on jan 1, 2017, zaheer abbas and others published physicochemical characterization of olmesartan medoxomil polymer solid dispersions by hot melt.
Effect of geometry on drug release from 3d printed tablets alvaro goyanes a , pamela robles martinez a , asma buanz a , abdul w.Basit a,b , simon gaisford a,b, a b.2 mm using a pharma 11 varicut pelletizer thermo fisher scientic, uk and mixed with paracetamol 2 g, 5 drug ww for 10 min in a turbula1 t2f shakermixer glen.
Filament was cut into small pieces 1 mm using a pharma 11 varicut pelletizer thermo fisher scientific, uk was milled in a wahl zx789 grinder wahl store, uk and sieved through a 1000 m mesh.The milled pva was mixed in a mortar and pestle with the drug.
The following 5 zones were fixed at 180 c.The die 2.5 mm was set at 175 c.The screw speed was held constant at 100 rpm.A spooler filabot was used to collect the filament, which was subsequently pelletized in 1.5 mm pellets 15 mmin, varicut pelletizer, thermo scientific.
I university of nairobi department of pharmaceutics and pharmacy practice formulation development of sustained release zidovudinelamivudine fixed dose combination paediatric mini matrices by hot melt extrusion by shital mahindra maru a thesis submitted in the fulfilment of the requirements for the degree of doctor of.
The commercial pva filament 38 g was cut into small pieces 2 mm using a pharma 11 varicut pelletizer thermo fisher scientific, uk and mixed with paracetamol 2 g, 5 drug ww for 10 min in a turbula t2f shakermixer glen mills inc., usa.